- Velpen, van der, V.
Publication date
January 2014
Publisher
Wageningen UR
Abstract
Background: Risk assessment can potentially be improved by closely linked experiments in the disciplines of epidemiology and toxicology. This was explored for isoflavones in a case study. For isoflavones potential beneficial health effects have been suggested, but discussions on their safety are ongoing as well. Aims and methods: Effects of isoflavone supplements on gene expression were studied in white blood cells (PBMCs) and adipose tissue, among postmenopausal women in two human intervention studies. To advance risk assessment, the dose response relation between intake and blood levels was studied with a log-linear regression model as well as the comparability of the human gene expression profiles with results from a rat experiment usi...
Extracted data
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- Mensink, M.R.
- Veer, P., van 't
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- Romani, Annalisa
- Tanini, Annalisa
- Vignolini, Pamela
- Brandi, Maria Luisa
January 2009
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- Zhang, Min
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[[alternative]]The effect of supplementation with isoflavones on plasma lipids, lipoproteins and urinary estrogen metabolites in postmenopausalwomen with hormone replacement therapy
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- [[author]]Chiu-Wei Huang
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[[abstract]]Isoflavones are soy phytoestrogens that have been suggested to be cardioprotective and a...
